Multiple studies have demonstrated that the positivity of Hh signaling molecules, such Sonic ligands, PTCH1 and GLIs, were about 50–70% in HCC specimens, which was much higher than the pericancerous liver tissue of a different base disease background, such as HBV or HCV infection or NAFLD [17,36,106]. Here, PTCH1 is linked to hepatocellular carcinoma.