HCC patients with less sestrin-3 expression had a tendency of worse survival, and sestrin-3 knock-out (KO) mice demonstrated a higher tumor burden and expression of stem markers (CD133 and CD44) compared to the wild-type group in a DEN combined with a choline-deficient high-fat diet (CD-HFD) model [73]. This evidence concerns the gene SESN3 and neoplasm.