CHMP5 and COVID-19: The different effects of the full-length S1 and RBD only-containing proteins may be important considering that BNT162b2 and many other COVID-19 vaccines express the full-length spike protein, while the BNT162b1 vaccine encodes only the RBD region [9,10,11,12,13,14,15,16,17,18,19,20].