STZ (2-deoxy-2-(3-(methyl-3-nitrosoureido) -D-glucopyranose), a DNA alkylating reagent, is often used to mimic diabetes symptoms for type I [14], depicted by pancreatic β-cells apoptosis, resulting in hyperglycemia, diminution of insulin gene expression, and reduced synthesis of insulin [15]. The gene discussed is INS; the disease is Hyperglycemia.