The mrDEGs in BC were shown to function in cancer-related biological processes, such as neural crest cell migration involved in autonomic nervous system development (e.g. FN1, semaphorin 3A (SEMA3A), semaphorin 3A (SEMA3F) and neuropilin 1 (NRP1)), regulation of cell migration (e.g. C-X-C motif chemokine ligand 2 (CXCL2), DDR2 and FN1), cell surface receptor signaling pathway (e.g. Microtubule Affinity Regulating Kinase 1 (MARK1), biglycan (BGN) and CXCL2) and cell differentiation (e.g. Ankyrin 2 (ANK2), Glypican 2 (GPC2) and melanocyte inducing transcription factor (MITF)). The gene discussed is MARK1; the disease is breast cancer.