To further study the prognostic potential of ZIC2 in liver cancer, we used the Kaplan–Meier plotter tool to evaluate the prognostic value of ZIC2. Poor prognosis of liver cancer was associated with higher ZIC2 expression (OS HR = 1.81, 95% confidence interval [CI]= 1.27–2.59, Logrank P=0.00096, Figure 4A; PFS HR = 1.73, 95% CI = 1.28–2.34, Logrank P=0.00027, Figure 4B), and the differences are statistically significant. This evidence concerns the gene ZIC2 and liver cancer.