ERBB2 and neoplasm: For HER-2 status determined using IHC alone (0, 1 + , and 2 + scores), although the concordance rate (52%) was slightly lower than in other published studies, the negative agreement was 100% for all tumours when HER-2 status was assessed by IHC-FISH as a dichotomous variable (HER-2-negative/HER-2-positive) according to reported recommendations [36].