STAT1 and severe acute respiratory syndrome: In the case of SARS-CoV-1, the causative agent of severe acute respiratory syndrome (SARS), open reading frame (ORF) 6 has been shown to target host IMPα, and sequester it at the rough ER/Golgi, to prevent its key role in mediating STAT-1 nuclear import, thus mollifying the host cell antiviral response [40].