We additionally show that after acute systemic infection with LCMV Armstrong virus, TSLP had a modest effect on primary CD8+ T-cell responses, with only a slight increase in Crlf2-/- cells in the spleen at day 8 p.i. Thus, TSLP can limit CD8+ T cell responses during primary viral infections, but the effect varied based on the tissue assessed and the type of viral infection. This evidence concerns the gene CD8A and viral infectious disease.