CASP3 and cancer: Two genes whose expression was markedly increased were Eps8l1 (epidermal growth factor receptor pathway substrate 8-like 1) and Eaf2. Eps8l1 has been reported to upregulate cell cycle genes, induce chemokines and enhance migration of some cancer cells (Yang et al., 2019; Huang et al., 2018; Zeng et al., 2018), whereas Eaf2 acts as an upstream modulator of non-canonical Wnt signaling, and has been suggested to suppress oxidative stress–induced apoptosis through inhibition of caspase 3 production and activation of Wnt3a signaling (Feng and Guo, 2018).