CRLF2 and infection: Finally, a third study used an adoptive co-transfer model of WT and Crlf2-/- TCR transgenic ovalbumin-specific CD8+ T cells (OT-I cells) and found that after infection with an OVA-expressing influenza virus, there were fewer Crlf2-/- OT I cells during the primary infection, indicating that TSLP enhances primary CD8+ T-cell responses (Shane and Klonowski, 2014).