Importantly, we also find that these four CF predicted modifiers (CLCA1, FABP1, MUC2, SLC4A4) tend to be co‐downregulated in those GTEx lung samples in which CFTR expression is low (all pairwise hypergeometric P‐values evaluating the overlap between pairs of these modifiers are < 0.05, Fig 2D). The gene discussed is CLCA1; the disease is cystic fibrosis.