PINK1‐, Parkin‐, and double‐KO mice show increased mitochondrial damage, ROS generation, inflammatory response, and serum creatinine (an index of renal dysfunction), raising the possibility that PINK1/Parkin‐mediated mitophagy prevents cell death and maintains renal function against I/R‐induced AKI (Tang et al, 2018). Here, PRKN is linked to acute kidney injury.