To further investigate the association of Cyclin D1 expression in breast cancer patients with different clinical parameters, HER2- (P=0.083), ER- (P=0.016), and ER+ (P=0.067) were found significant associated with OS and ER+ (P=0.018) and ER- (P=0.045) were significant with DFM in breast cancer (Figure 14). This evidence concerns the gene CCND1 and breast cancer.