The involvement of MITF in migration has mostly been characterized using knockdown studies in melanoma cell lines using either siRNA or shRNA and by using Matrigel-coated Boyden chambers (Carreira et al., 2006; Bianchi-Smiraglia et al., 2017; Cheli et al., 2011); in these studies, knocking down MITF resulted in increased migration properties. The gene discussed is MITF; the disease is melanoma.