Western blot showed that mesenchymal cell markers, including Fib, N‐cad and Vim, were induced by hypoxia, while HIF‐1α inhibition, p53 mutation, miRNA‐34a inhibition and Klotho overexpression (KL OE) via AAV‐Klotho full‐length plasmid infection decreased these markers. Here, TP53 is linked to infection.