2SMR analyses using the significant SNPs identified for FAAH (NAEs), SPTLC3 (CERs), CD83 (CERs), SGPP1 (CERs) and DEGS1 (CERs), as genetic instruments, in the CARDIOGRAMplusC4D cohort of 60 801 coronary artery disease cases and 123 504 controls (31), did not indicate a causal role of the NAE and CER species for which we detected GWAS significant association, in CAD (P > 0.05 for all). The gene discussed is DEGS1; the disease is coronary artery disorder.