We only found two genes that were completely discordant, thus completely oppositely regulated in COVID-19 and non-COVID-19 viral infections: Aconitase1 (ACO1) is over-expressed in COVID-19 and under-expressed in non-COVID-19 viral infections and Atlastin GTPase 3 (ATL3) is over-expressed in non-COVID-19 viral infections and under-expressed in COVID-19. The gene discussed is ACO1; the disease is viral infectious disease.