NRP1 and neoplasm: modified nanoparticles made of natural high‐density lipoproteins (HDLs) with the tumor‐penetrating peptide iRGD and loaded them with paclitaxel (PTX) and ICG (pHDL/PTX‐ICG) for synergetic chemo‐phototherapy.[96] After intravenous injection of pHDL/PTX‐ICG, iRGD mediated the binding with αv integrins on tumor endothelial cells and was then hydrolyzed and cleaved, exposing the binding site of Nrp‐1, and finally promoting tumor penetration.