Systematic review and meta-analysis done by Chiasakul et al. stated that irrespective of the zygosity status of the patient, ischemic stroke in a young patient is associated with the prothrombin gene mutation; however, although homozygous prothrombin gene mutation is less frequently found in the studies, exclusion of the study with the zero analysis brought the pooled OR of the homozygous prothrombin gene mutation way higher than its heterozygous counterpart [28]. The gene discussed is F2; the disease is ischemic stroke.