MET and non-small cell lung carcinoma: MET exon 14 skipping mutations, which the authors have identified in both NSCLC and SCLC patients, cause deletion of the juxtamembrane domain containing the casitas B-lineage lymphoma E3-ubiquitin ligase binding site, leading to a decrease in the turnover of the resulting aberrant MET protein and prolonged signal activation [6,26].