In a rotenone model of PD in mice [57], bee venom improved locomotor behavior impairments and reversed the rotenone-related reduction in brain dopamine, serotonin, norepinephrine, GSH levels and paraoxonase activity and the significant elevation in brain malondialdehyde, TNF-α, IL-β, DNA damage and over-expression of caspase-3, Bax and Bcl-2 genes [57]. The gene discussed is BAX; the disease is Parkinson disease.