Extensive vitreous hemorrhage prevents the laser photocoagulation hence it increases the complication of high-risk PDR.6,7 According to Protocol S study of diabetic retinopathy clinical research network two years for PDR.8 We in our study use the intravitreal anti-VEGF as adjunctive treatment along with PRP to compare the effectiveness in regression of neovessels in divided groups where in one group only PRP was done and in another group both IVB along with PRP was done. The gene discussed is VEGFA; the disease is diabetic retinopathy.