VEGFA and macular retinal edema: The gold standard treatment for PDR is Panretinal photocoagulation (PRP) but it has many side effects like pain during procedure, macular edema or exacerbation in macular edema, peripheral visual loss, deterioration in visual fields, uveal effusion syndrome and defect in color vision.1,2, According to some recent studies the progression of macular edema is due to the accumulation of leukocytes at the non-coagulated posterior pole, post laser release of inflammatory mediators and angiogenic growth factors such as VEGF.2