Syndecans function as coreceptors or activators for molecules like growth factors and constituents of the matrix.18 Regarding syndecan-1’s regulation mechanism of cell attachment, it was suggested that it is a co-receptor of bFGF Type-1 growth factor, which has also shown decreased expression in CRC compared to adenoma, similarly to syndecan-1.28 Fujiya et al. suggest that a loss of syndecan-1 may weaken the signals that maintain the cellular differentiation of CRC cells and result in dedifferentiation and detachment from the extracellular matrix and adjacent cells.12 Here, SDC1 is linked to adenoma.