EGFR and cancer: The enrichment analysis result of KEGG pathway show that the host genes of these upregulated circRNAs were most significantly enriched in Rap1 signaling pathway, ErbB signaling pathway, bacterial invasion of epithelial cells, proteoglycans in cancer, regulation of actin cytoskeleton, EGFR tyrosine kinase inhibitor resistance, vasopressin-regulated water reabsorption, prostate cancer, lysine degradation, and renal cell carcinoma (Fig. 4C).