In this study, we investigated whether SIRT1 is involved in TGF-β1-induced EMT during lung cancer cell migration and invasion, and found that its expression increased in TGF-β1-induced NSCLC cells, but Sal treatment inhibited TGF-β1-induced SIRT1 expression (Figure 3, 5). The gene discussed is TGFB1; the disease is lung carcinoma.