FHIT and neoplasm: Subsequent multiple evidences have suggested that FHIT plays an important role in suppressing cancer progression by regulating cell cycle, cell death, metastatic potential including epithelial-mesenchymal transition (EMT) as well as correlating global genomic instability with LOH of FHIT gene 4-7 Compared to the robust role in FHIT gene as a tumor suppressor, the mechanism underlying FHIT-induced biology is relatively less understood because of lack of information about the binding partner of FHIT protein as either tumor suppressor or oncogenic protein.