ERBB2 and neoplasm: Locoregional recurrence (LRR)-free survival in patients with the HR+/HER2- and HR+/HER2+ subtypes was excellent, regardless of tumour response to neoadjuvant chemotherapy; by contrast, patients with the HR-/HER2 + and HR-/HER2- subtypes who had a poor response to neoadjuvant treatment had a lower LRR-free survival rate, thus confirming a direct association between pathological complete response (pCR) and LRR-free survival.