Since CD8+ T cells mount IFN gamma (Ifn-γ) responses in the CNS during encephalitis, the role of IFN gamma (Ifn-γ) receptor (IfngR) signaling in neuronal damage has been investigated using Cx3cr1creER/+:Ifngrfl/fl mice.36 In these mice, tamoxifen injection after viral elimination from the CNS allowed the deletion of Ifn-γ receptor (IfngR) signaling in CNS resident CX3CR1+ myeloid cells, including microglia. The gene discussed is CD8A; the disease is viral encephalitis.