FOXO3 and coronary artery disorder: Our previous bioinformatics study profiled the molecular mechanisms of the herbal prescription SWTX against CHD through multi-level data integration, the multiple ingredients derived from SWTX may regulate many aspects of CHD, such as stress response, angiogenesis, immune inflammatory response, energy metabolism, endocrine regulation, etc., and the PI3K/Akt/FoxO3a pathway was identified to be one of the most correlated pathways8.