In vivo experiments, SWTX can effectively inhibit I/R injury in rats by reducing ST-segment elevation, pathological changes and myocardial infarct size and improving cardiac function, while SWTX up-regulate Pik3r1, Akt, down-regulate Bim gene, and inhibits the reduction of Akt1, FoxO3a phosphorylation mediated by I/R injury. This evidence concerns the gene FOXO3 and myocardial infarction.