Upon infection with herpes simplex virus 1 (HSV-1), viral protein ICP8 translocates HDAC1/CoREST/LSD1 to the cytoplasm, and ICP0 interacts with HDAC1 to disrupt the CoREST repressor complex and translocates HDAC1 to ND10 bodies26. Here, HDAC1 is linked to infection.