Finally, the production of macrophage proinflammatory cytokines playing an important role in the development of inflammatory bowel disease was evaluated, finding an important decrease in the release of TNF-α, IL-6, IFN-γ and IL-12 indomethacin-treated mice fed with probiotics compared to those on a conventional diet (Fig. 7D–G). The gene discussed is TNF; the disease is inflammatory bowel disease.