To our knowledge, the comparative study of serum pentraxin (SAP/CRP) protein, ferritin, TNF-α and IL-1β levels in patients with severe secondary and primary dengue fever in eastern India has not yet been well studied and our current study will help to initiate more studies to unravel the potential of pentraxin protein as a biomarker in dengue severity. The gene discussed is APCS; the disease is dengue disease.