According to a previous report, a mutational sequence analysis between a non-obese diabetes model (NOD/Lt) and a non-diabetic model (C57BL/6, C3H/HeJ and BALB/c) provided some candidate mutations of mouse Jaw1 that are related to type I diabetes such as G6D, L145P, duplication of three amino acids [STL (452-455)]44. The gene discussed is IRAG2; the disease is type 1 diabetes mellitus.