ATXN1 and Anxiety: This was accompanied by increased time in the open arms, another sign of decreased anxiety (Fig. 3B, 125% effect size with 95% confidence interval (56.9%, 193%), WT average 30.22 ± 4.745 s, ATXN1[82Q] average 67.99 ± 9.448 s, P = 0.0012, unpaired, two-tailed t-test).