ALS is associated with immune cell recruitment, glial cell inflammation and changes in immune parameters in the CSF and the blood12,13.Several studies reported increased levels of several blood and CSF biomarkers, including vascular biomarkers (ICAMs, VCAMs, VEGF) chemokines (MCP-1, Eotaxin) and cytokines (IL-6, IL-17, IL-8, IL-10, IFN-γ, TNF-α)4,14. This evidence concerns the gene TNF and amyotrophic lateral sclerosis.