Most importantly, Kaplan–Meier plots clearly indicated that 5-year survival rate was significantly better in cases of CRC with high expression on SDF-1 and CD8+ T-cell infiltration compared to tumors showing a high infiltration of CD8+ T-cells only 66% (95% CI 48–79%) versus 55% (95% CI 45–64%); p = 0.0004. The gene discussed is CD8A; the disease is colorectal carcinoma.