NOTCH1 and acute lymphoblastic leukemia: When Liu et al. used WES and/or WGS to profile the genetic landscape of T-ALL, NOTCH1 was found to be the most frequently mutated gene, with 264 sequence mutations, identified in 196 cases, and most mutations were in the heterodimerization domain (62.9%; 166/264) and the PEST domain (31.4%; 83/264).