For T-ALL-related pathogenesis pathways, impacted genes involved in the JAK-STAT signaling pathways, such as EP300 (4.69%), STAT5B (9.38%), JAK1 (12.50%), JAK3 (7.81%), IL7R (4.69%), and PTPN11 (3.13%) had mutation frequencies in the range of 3%–13% and were observed in 23 cases (35.94%). This evidence concerns the gene EP300 and acute lymphoblastic leukemia.