Previous studies have shown that the uptake of estradiol-3-sulfate in T47-D breast cancer cells could lead to increased cell proliferation via the Na+ transport system, and the uptake of estradiol-3-sulfate was mediated by OATP16,17, suggesting that OATP might promote the proliferation of breast cancer cells. The gene discussed is SLCO1A2; the disease is breast carcinoma.