In addition, we found that knockdown of SLCO1B3 led to an increased ability for MDA-MB-231 cells to penetrate the membrane, whereas overexpression of SLCO1B3 in BT-549 resulted in decreased cell number penetrating membrane, suggesting that SLCO1B3 is also involved in the invasion and migration of breast cancer cells, and the expression of SLCO1B3 can inhibit the migration and invasion of breast cancer cells. This evidence concerns the gene SLCO1B3 and breast carcinoma.