MKI67 and breast carcinoma: Univariate and multivariate COX analysis showed that lymph node metastasis (HR = 3.189 P = 0.001), tumor size (HR = 2.543, P = 0.007), vascular invasion (HR = 3.128, P = 0.033) , PR status (HR = 0.485, P = 0.030), menopausal status (HR = 0.474, P = 0.021) and Ki-67 index (HR = 3.041, P = 0.002) were independent prognostic factors for DFS in breast cancer patients (Table 2).