Herein, we aimed to examine the possible inhibitory effects of the novel FXR agonist nelumal A on colitis and inflammation-associated colon carcinogenesis, dextran sodium sulfate(DSS-induced colitis and azoxymethane (AOM) plus dextran sodium sulfate (DSS)-induced colitis and AOM plus DSS-induced colon carcinogenesis19. The gene discussed is NR1H4; the disease is colitis.