However, despite an increasing number of molecules recognized as skin cancer biomarkers, e.g. cytokines such as interleukin 6 (IL-6) or interferon gamma (IFN-γ)5, enzyme indoleamine-2,3-dioxygenase6, v-raf murine sarcoma viral oncogene homologue B1 (BRAF) gene mutations7, their applications are limited in terms of non-invasive diagnostics. This evidence concerns the gene IFNG and skin neoplasm.