However, our data indicated inhibition of trans-interaction by ectopic EPHA10 expression (Fig. S2), suggesting that upregulation of both EPHA10 and EFNA4 in OSCC tissues increased cis-interactions, and that upregulation of EFNA4 in cancer tissues was enough to induce the downstream effects of EFNA4-EPHA10 forward signaling. This evidence concerns the gene EFNA4 and cancer.