Moreover, when excluding PPMS, as in a previous study13, PI and MS severity scores (MSSS)31 were lower in southern MS patients with HLA-DRB1*04:05 than in those without the allele (p = 0.22 and 0.050, respectively) (Supplementary Table S4). The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.