When we compared the clinical characteristics of MS patients with HLA-DRB1*04:05 (excluding PPMS) between northern and southern Japan, northern patients had a lower number of relapses (p < 0.001) and annualized relapse rate (p = 0.006) but higher PI (p = 0.018) and MSSS (p = 0.008). The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.