In agreement, we found only a subset of macrophages expresses GAL1R and GAL2R in a xanthelasma of the skin10, a small proportion of granulocytes in human glioma and pituitary adenoma expresses GAL2R, and subpopulations of glioma-associated macrophages/microglia express GAL1R, GAL2R and GAL3R, with GAL3R being the most abundant GALR subtype in tumor-infiltrating immune cells38. Here, GALR2 is linked to central nervous system cancer.