In summary, our study is the first to identify the role in sarcoma progression of differentially methylated genes (PTPRN2 and DAXX in LMS; WT1-AS and TNXB in SS; VENTX and NTRK3 in Ple-RMS and MEST and C14MC / miR-379/miR-656 cluster in MFS) that have been previously described in context of carcinoma progression and metastasis. Here, VENTX is linked to Marfan syndrome.