Miyata et al.45, on a methylation analysis of a limited number of normal myometrium, leiomyomas and leiomyosarcoma (n = 9 samples in total) identified global hypomethylation in LMSs, which is consistent with our findings, including overlapping genes (PDE6B, PRODH, HSPA2, LTB4R, HEPACAM, RAP1GAP2, ADAM32, ADARB2, PDE9A, SPTBN1, VIPR2, KCNQ1, PTPRN2, MTMR7, MCF2L and KCNQ1). Here, VIPR2 is linked to leiomyosarcoma.