In a single study in breast cancer cells, PTPRN2 was shown to regulate actin dynamics, enhancing metastatic migration40 and based on this, we can hypothesise that PTPRN2 is also likely to act as a key regulator in the metastatic cascade of leiomyosarcomas but functional analyses are required to confirm this. The gene discussed is PTPRN2; the disease is leiomyosarcoma.