EPHA2 and nasopharyngeal carcinoma: Therefore, with advances in NPC genomics, chromatin modifications enhance EBV load as a key feature of the NPC genome.24 Moreover, BALF2_CCT, as a high-risk subtype of EBV, promotes the progression of NPC in South China and facilitates early identification of high-risk individuals.25 In addition, Ephrin receptor A2 (EphA2), an epithelial growth factor-associated receptor, benefits EBV entry into epithelial cells.26 Importantly, common fragile regions are favored loci for EBV integration, which are genomic hotspots for DNA damage and vulnerable to genomic rearrangements.