FOXO3 and nasopharyngeal carcinoma: For example, the forkhead box O (FOXO) family of proteins is an important transcriptional regulator of pivotal proteins associated with many diverse cellular functions.356 Among them, FOXO3a has been extensively studied because of its unique role in the regulation of cell proliferation, apoptosis, metabolism, stress management, and longevity.357 In NPC, silencing FOXO3a promotes tumor radioresistance of NPC in vitro and in vivo through inducing EMT and activating Wnt/β-catenin signal pathway.