For example, EBV-LMP1 remodels the mitochondria by regulating the AMPK/Drp1 and cyclin B1/Cdk1/Drp1 axes,101 or decreases TRAIL-induced apoptosis by activating the PI3-K/AKT/FOXO3a signaling pathway.344 In addition, EBV-LMP1 modulates MAPK-mediated Op18/stathmin signaling to induce cell cycle progression and promote tumorigenesis.345 SiRNA-mediated silencing of stathmin may enhance the efficacy of paclitaxel in the treatment of NPC.346. The gene discussed is PIK3CA; the disease is nasopharyngeal carcinoma.