The LMP1-perturbed PI3-K/Akt-GSK3β-FBW7 signaling axis resulted in the stabilization of c-Myc, which was confirmed to be crucial for LMP1-induced glycolysis and confers NPC cells resistance to apoptosis.98 Lu et al.99 revealed a novel mechanism for LMP1-mediated radio-resistance by suppressing the DNA damage response (DDR) through DNA-PK/AMPK signaling. This evidence concerns the gene PIK3CA and nasopharyngeal carcinoma.