It is supposed that FOXO3a can be a novel and reliable NPC marker and a potential therapeutic target against NPC.358 Guo et al.359 reported genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with distant metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy. The gene discussed is PTEN; the disease is nasopharyngeal carcinoma.