And the interaction is mediated by the EphA2 extracellular domain (ECD).266,267 In addition, Peng et al.268 have identified that small-molecular inhibitor of EphA2, ALW (ALW-II-41–27), strongly inhibited the proliferation of gastric cancer in vitro and in gastric cancer patient–derived xenografts. The gene discussed is EPHA2; the disease is gastric cancer.