The first association of EBV infection with breast cancer was reported in 1995.31 Recently, several studies showed that EBV infection leads to more malignant transformation of breast epithelial cells and affects patient prognosis.32,33 EBV leads to a 4.74-fold increase in risk of breast cancer development compared with a control group.32 The potential oncogenesis mechanism of EBV is related to viral proteins, such as LMP1 that activate the Her2/Her3 signaling cascades.33 Here, ERBB3 is linked to Epstein-Barr virus infection.