SOX2 and cancer: Targeting cancer stem cells (CSCs) by a novel antagonist of IAPs, APG-1387, induced autophagic degradation of sex-determining region Y (SRY)-box 2 (Sox2), suggesting that APG-1387 combined with chemotherapy might be a novel therapeutic strategy for the treatment of NPC.322 The search for anticancer agents originating from natural compounds has been a booming area of research in recent years due to their perceived low toxicity.