LMP1-mediated FGFR1 activation contributes to aerobic glycolysis and transformation of epithelial cells, thereby implicating FGF2/FGFR1 signaling activation in the EBV-driven pathogenesis of NPC.103 EBV-LMP1 induces glycolytic addiction to enhanced cell motility in nasopharyngeal epithelial cells. Here, PDLIM7 is linked to nasopharyngeal carcinoma.