EBV could regulate its own tumorigenesis through the LMP1/NF-κB/exo-LMP1 axis, opening a new avenue for understanding the pathogenesis of this tumor virus and providing a rationale for the use of exo-LMP1 or exosomal miR-203 (exo-miR-203) in EBV-targeted therapy by aspirin in invasive NPC. The gene discussed is NFKB1; the disease is neoplasm.