TET family proteins, especially TET2, are downregulated during EBV infection, and TET2 may function as a resistance factor against EBV-induced DNA methylation acquisition.68 TET enzymes require α-ketoglutarate (α-KG) as an essential co-substrate to catalyze the conversion of 5-mC to 5-hmC. The gene discussed is TET2; the disease is Epstein-Barr virus infection.