In the 1980s, the EBNA protein was detected in HRS cells of a HL patient44 and then EBV genome was sequenced in HL and NK/T-cell lymphoma.45 Also, ENK/T-cell lymphoma was characterized by EBV infection of T or NK cells, which express a latency II pattern with variable LMP1 expression. This evidence concerns the gene PDLIM7 and Epstein-Barr virus infection.