More importantly, EBV-encoded miRNAs compromise the attraction of CD8+ T cytotoxic lymphocytes into the tumor microenvironment by down-regulating CXCL11 expression and also inhibit antigen presentation on MHC class I molecules to these CD8+ T cells, rendering the microenvironment of EBV-associated malignancies immune-suppressive.231. The gene discussed is CD8A; the disease is neoplasm.