What makes more sense is that metformin interrupts the AMPKɑ/ p-Drp1 Ser637 signaling pathway or cucurbitacin E targets the cyclinB1-Cdk1/p-Drp1 (Ser616) axis repressing mitochondrial fission.101 This discovery supports the mitochondrial dynamics markers Drp1 Ser616 and Ser637 as crucial targets for NPC in the future. This evidence concerns the gene PRKAA1 and nasopharyngeal carcinoma.