S100A4 and Hodgkins lymphoma: For example, the S100 calcium binding protein A4 (S100A4) is overexpressed in LMP2A-positive NPC tissues and DNA hypomethylation plays a critical role in S100A4 regulation.75 In Hodgkin’s lymphoma, a set of tumor-related genes known to be silenced by promoter hypermethylation (e.g., RASSF1, DAPK, MGMT) are more frequently hypermethylated in EBV-negative compared to EBV-positive cases.76 EBV might also take part in the redistribution of DNA methylation modification sites.