Triptolide, a diterpene epoxide of the tristeza extract, has been shown to target EBNA1, inhibit proliferation of EBV-positive NPC cells, and induce cell death through a caspase-9-dependent pathway.151 For example, extranodal natural killer/T-cell lymphoma (ENKTL) is characterized by EBV latent infection with the expression of EBNA1 and LMP1. This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.