Ectopic expression of HoxC8 inhibits NPC cell growth in vitro and in vivo, modulates glycolysis and regulates the expression of TCA cycle-related genes.100 Recently, Luo et al.67 analyzed the metabolites of 13C6-d-glucose-traced NPC cells by using gas chromatography/mass spectrometry (GC/MS), and found that glycolytic flux in LMP1-overexpressing cells was markedly increased by about 90% compared to that in LMP1-negative cells. The gene discussed is HOXC8; the disease is nasopharyngeal carcinoma.