Other key biallelic events included DIS3, RB1, FAM46C, and TRAF3. Interestingly, biallelic DIS3, which has been associated with an adverse outcome in MM18, was present in 5% of MM cases vs. only 2% of SMM cases, again consistent with it being associated with a more aggressive disease phenotype. This evidence concerns the gene RB1 and Miyoshi myopathy.