In this study, we investigated NF-κB signaling in the PFC of bipolar disorder subjects by quantifying mRNA levels for NF-κB family members (NF-κB1, NF-κB2, RelA, RelB, and cRel), receptors that initiate NF-κB signaling (IL-1R, TNFR), NF-κB transcriptional activity-regulated products (IFITMs), and an NF-κB inhibitor (HIVEP2). Here, TNFRSF1A is linked to bipolar disorder.