We tested the hypotheses that in the PFC of subjects with bipolar disorder, transcript levels are (1) higher for NF-κB family members and activation receptors, (2) higher for immune markers that are regulated by NF-κB activity (i.e. IFITMs) and (3) lower for an NF-κB inhibitor (i.e. HIVEP2). The gene discussed is NFKB1; the disease is bipolar disorder.