IL1R1 and bipolar disorder: Furthermore, both IL-1R and TNFR mRNA levels were each correlated with mRNA levels for NF-κB2, RelA, and cRel across all subjects (all r ≥ 0.56, all p < 0.00001), in bipolar disorder subjects alone (all r ≥ 0.73, all p < 0.00001), and in comparison subjects alone (all r ≥ 0.45, all p ≤ 0.001; Table 2).