TGFB1 and colorectal carcinoma: Furthermore, SW480/DDX39B cells were treated with a TGFβ signaling pathway inhibitor (SB431542); western blotting and Transwell assays showed that SB431542 abrogated the effect of DDX39B in enhancing the TGFβ signaling pathway and reduced the effect of DDX39B in facilitating CRC metastasis (Fig. 6C, D).