circNDUFB2 is frequently downregulated in NSCLC compared with matched adjacent nontumorous tissues, and decrease of QKI contributes to the downregulation of circNDUFB2. Functionally, circNDUFB2 inhibits NSCLC progression through destabilizing IGF2BPs and activating anti-tumor immunity. The gene discussed is QKI; the disease is non-small cell lung carcinoma.