RIG-I-like receptor (RLR) family comprises retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), as well as laboratory of genetics and physiology 2 (LGP2), recognizes viral RNAs in the cytoplasm and triggers innate immune responses against viral infection through the production of IFNs and proinflammatory cytokines35–42. The gene discussed is DHX58; the disease is viral infectious disease.