In this study, we identify circNDUFB2 is frequently downregulated in NSCLC tissues, and decrease of QKI contributes to the downregulation of circNDUFB2. circNDUFB2 not only promotes IGF2BPs ubiquitination degradation by forming TRIM25/circNDUFB2/IGF2BPs ternary complex, but also triggers cellular immune responses by activating RIG-I. The gene discussed is TRIM25; the disease is non-small cell lung carcinoma.