It was observed in human breast cancer cells BT474 that POGLUT1 overexpression in the presence of TGF-β1 improved cell viability and inhibited p16 upregulation through TGF-β1 pathway, suggesting the involvement of POGLUT1 in BT474 cell proliferation104 (Fig. 6b). This evidence concerns the gene POGLUT1 and breast carcinoma.