Similarly, nivolumab in combination with ipilimumab (an IgG1 mAb against CTLA-4) and standard therapy cetuximab/platinum/5FU (NCT02741570) or with ulocuplumab (a fully human anti-CXCR4, NCT02472977) is also being investigated in LA/M HNSCC tumors. Here, CTLA4 is linked to head and neck squamous cell carcinoma.