Sato et al. showed that HNSCC cells secreted EVs carry ephrin type B receptor 2 (EPHB2), promoting angiogenesis by inducing the STAT3 signaling pathway in endothelial cells.144 Another study showed that tumor-derived exosomes (a form of EV) carry coagulation factor III, IGFBP-3, uPA, thrombospondin-1, endostatin, and uPA. This evidence concerns the gene EPHB2 and neoplasm.