Additionally, IL-6 secreted by tumor and many stromal cells through upregulation of Snail via the STAT3 pathway, and stabilizing Twist via casein kinase 2 (CK2) promote HNSCC EMT.116 Hypoxia is the vital component of TME and a vital contributor to metastasis and has been shown to induce EMT. The gene discussed is TWIST1; the disease is neoplasm.