As compared to HPV−ve tumors, HPV+ve OPCs have higher CD3+ and CD8+ TILs,64 suggesting a more antitumor immune response.54,62 Based on these studies, immunological biomarkers or immunoscore with the diagnostic and predictive outcome has been developed.93 The immunoscore quantifies CD3+ and CD8+ TILs in the tumor core and the invasive margin of resected tumors. Here, CD8A is linked to neoplasm.