Zhou et al.93 found that in mice with DSS-induced colitis, eliminating YAP expression in macrophages increases the abundance of the IBD-attenuating gut microbiota (Lactobacillus, Bacteroides, and Bifidobacterium) and decreases gut flora associated with IBD deterioration (Prevotella, β-Proteobacteria, γ-Proteobacteria, and Enterobacteriaceae) compared with that of the control group138–140. The gene discussed is YAP1; the disease is inflammatory bowel disease.